Anti-eIF4G1 (phospho S1108) antibody [SP351],Abcam,AB223502

Host

Rabbit

Reactivity

Human

Application

IHC-P

Platform ID

BAB916217000

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-eIF4G1 (phospho S1108) antibody [SP351]
Cat. No.AB223502
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P
ClonalityMonoclonal
Clone NumberSP351
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A/G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.6 Preservative: 0.099% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed : 29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed : 29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed : 29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed : 29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed : 29062139). See full target information EIF4G1 phospho S1108

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