Anti-eRF3/GSPT1 antibody,Abcam,AB126090
What is this antibody validated in? Anti-eRF3/GSPT1 antibody (ab126090) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples. What is the molecular weight of eRF3/GSPT1? Anti-eRF3/GSPT1 (ab126090) specifically detects a band for eRF3/GSPT1 (UniProt: P15170) at a molecular weight of 69kDa.
Host
Rabbit
Reactivity
Human
Application
WB, IHC-P
Platform ID
BAB420464960
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed : 15987998, PubMed : 19417105, PubMed : 2511002, PubMed : 27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons : The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed : 27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed : 16777602, PubMed : 27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed : 24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed : 30682371). See full target information GSPT1
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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