Anti-gamma H2A.X (phospho S139) antibody,Abcam,AB2893

Anti-gamma H2A.X (phospho S139) antibody (ab2893) is a rabbit polyclonal antibody and is validated for use in ICC/IF, WB in human, mouse, rat samples. Anti-gamma H2A.X (phospho S139) antibody (ab2893) has been cited over 394 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-gamma H2A.X (phospho S139) antibody (ab2893) has high sensitivity and specificity. Anti-gamma H2A.X (phospho S139) antibody (ab2893) has 32 independent reviews from customers. Anti-gamma H2A.X (phospho S139) antibody (ab2893) specifically detects gamma H2A.X Phospho-S139 (UniProt ID: P16104; Molecular weight: 15kDa) and is sold in 50 µg selling sizes. ab2893 is batch tested in peptide array, western blot and ICC only, although some customers have successfully used this product in IHC and ChIP (see images below). We would recommend ab81299 as an alternative product for use in IHC and ChIP.

Host

Rabbit

Reactivity

Human, Rat, Mouse

Application

WB, ICC/IF

Platform ID

BAB501537291

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-gamma H2A.X (phospho S139) antibody
Cat. No.AB2893
HostRabbit
IsotypeIgG
ReactivityHuman, Rat, Mouse
ApplicationWB, ICC/IF
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. See full target information H2AX phospho S139 + S139

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