Anti-iNOS antibody [EPR16635] - Mouse IgG2b (Chimeric),Abcam,AB210823

What is this antibody validated in? Anti-iNOS antibody [EPR16635] - Mouse IgG2b (Chimeric) (ab210823) is a mouse recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples. What is the molecular weight of iNOS? Anti-iNOS [EPR16635] - Mouse IgG2b (Chimeric) (ab210823) specifically detects a band for iNOS (UniProt: P35228) at a molecular weight of 131kDa. Trusted by the scientific community Anti-iNOS [EPR16635] - Mouse IgG2b (Chimeric) (ab210823) was first used in a scientific publication in 2016 and has been cited over 10 times in peer-reviewed journals. Other related products We have a range of other formats of antibody clone [EPR16635] also available for your convenience: ab178945 , Alexa Fluor® 647 - ab209027 , Alexa Fluor® 555 - ab209594 , Alexa Fluor® 568 - ab209595 , ab210823, Carrier free - ab213987 , Carrier free - ab275330

Host

Mouse

Reactivity

Mouse

Application

WB, ICC/IF

Platform ID

BAB731060860

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-iNOS antibody [EPR16635] - Mouse IgG2b (Chimeric)
Cat. No.AB210823
HostMouse
IsotypeIgG2b
ReactivityMouse
ApplicationWB, ICC/IF
ClonalityMonoclonal
Clone NumberEPR16635
Concentration0.966 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed : 7504305, PubMed : 7531687, PubMed : 7544004, PubMed : 7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed : 25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed : 19688109). See full target information NOS2

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