Anti-kynurenine 3-monooxygenase antibody,Abcam,AB233529

Host

Rabbit

Reactivity

Rat

Application

IHC-P, WB

Platform ID

BAB617292966

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-kynurenine 3-monooxygenase antibody
Cat. No.AB233529
HostRabbit
IsotypeIgG
ReactivityRat
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration0.34 - 1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human kynurenine 3-monooxygenase aa 1-300. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed : 23575632, PubMed : 26752518, PubMed : 28604669, PubMed : 29208702, PubMed : 29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). See full target information kynurenine 3-monooxygenase

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