Anti-mGluR1 antibody,Abcam,AB153669

Do not freeze this antibody unless you want to store it for a long period of time.

Host

Chicken

Reactivity

Mouse

Application

IHC-FoFr

Platform ID

BAB697065921

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-mGluR1 antibody
Cat. No.AB153669
HostChicken
IsotypeIgY
ReactivityMouse
ApplicationIHC-FoFr
ClonalityPolyclonal
Concentration0.3 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human GRM1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.02% Sodium azide Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed : 24603153, PubMed : 28886343, PubMed : 7476890). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed : 24357660, PubMed : 27276689). See full target information GRM1

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