Anti-p107 antibody,Abcam,AB244504

Host

Rabbit

Reactivity

Human

Application

ICC/IF, IHC-P, WB

Platform ID

BAB160422254

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-p107 antibody
Cat. No.AB244504
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, IHC-P, WB
ClonalityPolyclonal
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human RBL1 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Key regulator of entry into cell division (PubMed : 17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed : 8319904). May act as a tumor suppressor (PubMed : 8319904). See full target information RBL1

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