Anti-p107 antibody,Abcam,AB245514

ab245514 has not performed satisfactorily when used for WB of p107 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of p107.

Host

Rabbit

Reactivity

Human

Application

IP, WB

Platform ID

BAB472928501

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-p107 antibody
Cat. No.AB245514
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIP, WB
ClonalityPolyclonal
ImmunogenSynthetic Peptide within Human RBL1 aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Key regulator of entry into cell division (PubMed : 17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed : 8319904). May act as a tumor suppressor (PubMed : 8319904). See full target information RBL1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.