Anti-p114RhoGEF antibody,Abcam,AB96520

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

WB, IHC-P

Platform ID

BAB410447242

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-p114RhoGEF antibody
Cat. No.AB96520
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationWB, IHC-P
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ARHGEF18 aa 600-850. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed : 22006950). See full target information ARHGEF18

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