Anti-p114RhoGEF antibody [OTI6D10],Abcam,AB236374

Host

Mouse

Reactivity

Human

Application

IHC-P, WB

Platform ID

BAB722953489

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-p114RhoGEF antibody [OTI6D10]
Cat. No.AB236374
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P, WB
ClonalityMonoclonal
Clone NumberOTI6D10
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ARHGEF18 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed : 22006950). See full target information ARHGEF18

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