Anti-p27 KIP 1 antibody [DCS-72.F6],Abcam,AB3928

Host

Mouse

Reactivity

Human

Application

IHC-P

Platform ID

BAB098240851

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-p27 KIP 1 antibody [DCS-72.F6]
Cat. No.AB3928
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P
ClonalityMonoclonal
Clone NumberDCS-72.F6
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Mouse Cdkn1b.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Important regulator of cell cycle progression (PubMed : 12972555, PubMed : 8033213). Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes (PubMed : 8033213). Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. See full target information Cdkn1b

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