Anti-p27 KIP 1 antibody [SX53G8],Abcam,AB193379

Host

Mouse

Reactivity

Human, Monkey, Mouse, Rat

Application

IHC-P, ICC/IF, WB, ICC, IHC-Fr, IP, Flow Cyt

Platform ID

BAB910797074

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-p27 KIP 1 antibody [SX53G8]
Cat. No.AB193379
HostMouse
IsotypeIgG1
ReactivityHuman, Monkey, Mouse, Rat
ApplicationIHC-P, ICC/IF, WB, ICC, IHC-Fr, IP, Flow Cyt
ClonalityMonoclonal
Clone NumberSX53G8
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human CDKN1B.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed : 28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. See full target information CDKN1B

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