Anti-p53 antibody [9.1],Abcam,AB77813

Target data Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. Positively regulates apoptosis in the early-stage embryo in response to UV irradiation (PubMed : 15529176). See full target information Cellular tumor antigen p53