Anti-p63 antibody [EPR5701],Abcam,AB124762

Product Specifications Anti-p63 antibody [EPR5701] (ab124762) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, WB, mIHC in human, mouse, rat samples. Anti-p63 antibody [EPR5701] (ab124762) specifically detects p63 (UniProt ID: Q9H3D4; Molecular weight: 77kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-p63 antibody [EPR5701] (ab124762) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-p63 antibody [EPR5701] (ab124762) has been cited over 138 times in peer reviewed journals and is trusted by the scientific community. Anti-p63 antibody [EPR5701] (ab124762) has 11 independent reviews from customers. Related Products Antibody clone EPR5701 is also available pre-conjugated to a variety of labels for your convenience - HRP, Biotin, Alexa Fluor® 488, Alexa Fluor® 647 ( ab202357 , ab202861 , ab246727 , ab246728 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

Flow Cyt (Intra), WB, IHC-P, mIHC, ICC/IF

Platform ID

BAB099840083

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-p63 antibody [EPR5701]
Cat. No.AB124762
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationFlow Cyt (Intra), WB, IHC-P, mIHC, ICC/IF
ClonalityMonoclonal
Clone NumberEPR5701
Concentration0.905 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. See full target information TP63

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