Arg3.1 (D6H9N) Rabbit Monoclonal Antibody#65650,Cell Signaling Technology (CST),65650

Arg3.1 (D6H9N) Rabbit Monoclonal Antibody recognizes endogenous levels of total Arg3.1 protein. A band of unknown origin is detected ~40kDa in some rodent samples.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000

Platform ID

BAB588851682

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameArg3.1 (D6H9N) Rabbit Monoclonal Antibody#65650
Cat. No.65650
Accession NumberQ7LC44
Gene ID (Entrez)23237
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000
Molecular Weight51
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Arg3.1, also known as Arc for activity-regulated cytoskeleton-associated protein, is an immediate early gene whose expression is necessary for synaptic plasticity (1). Arg3.1 expression is induced by many experimental stimuli such as LTP (2), LTD (3), and learning. Arg3.1 is also involved in the regulation of synaptic strength and homeostatic scaling by promoting AMPA receptors endocytosis (5,6). Arg3.1 dysregulation has been proposed to participate in cognitive decline during aging (7).Guzowski, J.F. et al. (1999)Nat Neurosci2, 1120-4.Lyford, G.L. et al. (1995)Neuron14, 433-45.Guzowski, J.F. et al. (2000)J Neurosci20, 3993-4001.Guzowski, J.F. et al. (2001)J Neurosci21, 5089-98.Chowdhury, S. et al. (2006)Neuron52, 445-59.Rial Verde, E.M. et al. (2006)Neuron52, 461-74.Fletcher, B.R. et al. (2014)Neurobiol Learn Mem115, 58-67.Alternate Namesactivity regulated cytoskeleton associated protein; Activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein homolog; ARC; ARC/ARG3.1; Arg3.1; hArc; KIAA0278

Synonyms

activity regulated cytoskeleton associated protein; Activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein homolog; ARC; ARC/ARG3.1; Arg3.1; hArc; KIAA0278

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.