Arginase-1 Antibody (YA6101),MedChemexpress,HY-P86409

ARG1 is a key enzyme in the urea cycle, converting L-arginine to urea and L-ornithine, which is further metabolized into proline and polyamides that drive collagen synthesis and bioenergetic pathways essential for cell proliferation, respectively. The urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys. In nonhepatic tissues, ARG1 regulates L-arginine homeostasis by competing with nitric oxide synthase (NOS) and arginase for intracellular arginine. Arginine metabolism is a critical modulator of innate and adaptive immune responses. In polymorphonuclear granulocytes (PMN), ARG1 participates in an antimicrobial effector pathway. Upon PMN cell death, it is released from the phagolysosome, depleting arginine in the microenvironment and suppressing T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s), ARG1 promotes acute type 2 lung inflammation and supports optimal ILC2 proliferation (by similarity). In humans, the immunological role of ARG1 in the monocytic/macrophage/dendritic cell (DC) lineage remains uncertain.