Arginase-1 (D4E3M) Rabbit Monoclonal Antibody (SignalFlex^TMmFluor^TMRed 780 Conjugate)#76580,Cell Signaling Technology (CST),76580

L-arginine plays a critical role in regulating the immune system (1-3). In inflammation, cancer, and certain other pathological conditions, myeloid cell differentiation is inhibited leading to a heterogeneous population of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs). MDSCs are recruited to sites of cancer-associated inflammation and express high levels of arginase-1 (4). Arginase-1 catalyzes the final step of the urea cycle converting L-arginine to L-ornithine and urea (5). Thus, MDSCs increase the catabolism of L-arginine resulting in L-arginine depletion in the inflammatory microenvironment of cancer (4,6). The reduced availability of L-arginine suppresses T cell proliferation and function and thus contributes to tumor progression (4,6). Arginase-1 is of great interest to researchers looking for a therapeutic target to inhibit the function of MDSCs in the context of cancer immunotherapy (7). In addition, research studies have demonstrated that arginase-1 distinguishes primary hepatocellular carcinoma (HCC) from metastatic tumors in the liver, indicating its value as a potential biomarker in the diagnosis of HCC (8,9).Albina, J.E. et al. (1989)J Exp Med169, 1021-9.Mills, C.D. (2001)Crit Rev Immunol21, 399-425.Rodriguez, P.C. et al. (2004)Cancer Res64, 5839-49.Gabrilovich, D.I. and Nagaraj, S. (2009)Nat Rev Immunol9, 162-74.Wu, G. and Morris, S.M. (1998)Biochem J336 (Pt 1), 1-17.Raber, P. et al. (2012)Immunol Invest41, 614-34.Wesolowski, R. et al. (2013)J Immunother Cancer1, 10.Sang, W. et al. (2015)Tumour Biol36, 3881-6.Geramizadeh, B. and Seirfar, N. (2015)Hepat Mon15, e30336.Alternate NamesARG1; ARGI1; arginase 1; Arginase-1; arginase, liver; Liver-type arginase; Type I arginase

ARG1; ARGI1; arginase 1; Arginase-1; arginase, liver; Liver-type arginase; Type I arginase