B7-H3/CD276 Polyclonal Antibody,Bioss,bs-11019R

Host

Rabbit

Reactivity

Human

Application

WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC)

Conjugate

Unconjugated

Platform ID

BAB854756400

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameB7-H3/CD276 Polyclonal Antibody
Cat. No.bs-11019R
Accession NumberQ5ZPR3
Gene ID (Entrez)80381
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC)
Working DilutionsWB:1:300-5000 | ELISA:1:500-1000 | IHC-P:1:200-400 | IHC-F:1:100-500 | IF(IHC-P):1:50-200 | IF(IHC-F):1:50-200 | IF(ICC):1:50-200
ClonalityPolyclonal
Concentration1ug/ul
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4_. Store at -20_ for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Synonyms

B7H3; B7-H3; B7RP-2; 4Ig-B7-H3; CD276 antigen; B7 homolog 3; Costimulatory molecule; CD276; PSEC0249; UNQ309/PRO352

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