B7-H4 (D1M8I) Rabbit Monoclonal Antibody#14572,Cell Signaling Technology (CST),14572

B7 homolog 4 (B7-H4, VTCN1) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses (1-3). B7-H4 protein contains two extracellular Ig-like V-type domains, a transmembrane domain, and a short, two amino acid intracellular domain (3). The B7-H4 protein is shown to inhibit T cell activation, proliferation, and cytokine production (1,4,5). Although B7-H4 mRNA is widely expressed, B7-H4 protein is restricted to antigen-presenting cells and B cells (1). The B7-H4 protein is also found in several tumor types, including ovarian cancer and breast cancer (6). Research studies indicate that B7-H4 protein is present on the surface of ovarian tumor cells, and that targeted inhibition of B7-H4 using recombinant antibodies restores T cell activation pathways. These studies suggest some potential therapeutic value in blocking B7-H4 function and restoring T cell function in cancer patients (7,8).Sica, G.L. et al. (2003)Immunity18, 849-61.Prasad, D.V. et al. (2003)Immunity18, 863-73.Zang, X. et al. (2003)Proc Natl Acad Sci U S A100, 10388-92.He, C. et al. (2011)Clin Dev Immunol2011, 695834.Yi, K.H. and Chen, L. (2009)Immunol Rev229, 145-51.Salceda, S. et al. (2005)Exp Cell Res306, 128-41.Dangaj, D. and Scholler, N. (2013)Oncoimmunology2, e25913.Dangaj, D. et al. (2013)Cancer Res73, 4820-9.Alternate NamesB7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7-H4; B7h.5; B7H4; B7S1; B7X; FLJ22418; Immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RP11-229A19.4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; VCTN1; VTCN1

B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7-H4; B7h.5; B7H4; B7S1; B7X; FLJ22418; Immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RP11-229A19.4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; VCTN1; VTCN1