BAG6 (F8F6T) Rabbit Monoclonal Antibody#78988,Cell Signaling Technology (CST),78988

BAG6 (BCL2-associated athanogene-6), alternately known as BAT3 (HLA-B-associated transcript 3), was originally identified as a gene within the class III region of the human major histocompatibility complex, but has subsequently been found to exhibit protein chaperone activity. BAG6, in conjunction with other chaperone proteins and ubiquitin ligases, regulates protein stability and insertion of tail-anchored membrane proteins into the endoplasmic reticulum (ER) (1-3). The BAT3 complex, consisting of BAG6, TRC35, and Ubl4a localizes to ribosomes synthesizing membrane proteins and facilitates tailed-anchored protein capture by TRC40 and subsequent insertion of the nascent protein in to the ER membrane (4,5). BAG6 also plays a critical role in clearing cells of mis-folded and mis-localized peptides via ER-associated degradation and the ubiquitin-proteasome system (1,6,7). BAG6 may also act as a chaperone for glycoproteins through its interaction with DERLIN2 (8).In addition to its role as a chaperone, BAG6 has also been implicated in regulating chromatin structure and gene expression. For example, BAG6 and SET1A act as binding partners for BORIS to effect changes of chromatin structure and gene expression (9). Similarly, increased expression of BAG6 induces p300-mediated acetylation of p53, which is required for DNA damage response (10). BAG6 has also been found to interact with TGF-β, and in so doing acts as a positive regulator of TGF-β1 stimulation of type 1 collagen expression (11). BAG6 also suppresses bone morphogenic protein (BMP) signaling via its interaction with and regulation of small C-terminal domain phosphatase (SCP) that dephosphorylates SMAD proteins, resulting in subsequent termination of BMP-mediated events (12).Hessa, T. et al. (2011)Nature475, 394-7.David, R. (2011)Nat Rev Mol Cell Biol12, 550.Ast, T. and Schuldiner, M. (2011)Curr Biol21, R692-5.Mariappan, M. et al. (2010)Nature466, 1120-4.Leznicki, P. et al. (2010)J Cell Sci123, 2170-8.Minami, R. et al. (2010)J Cell Biol190, 637-50.Wang, Q. et al. (2011)Mol Cell42, 758-70.Claessen, J.H. and Ploegh, H.L. (2011)PLoS One6, e28542.Nguyen, P. et al. (2008)Mol Cell Biol28, 6720-9.Sasaki, T. et al. (2007)Genes Dev21, 848-61.Kwak, J.H. et al. (2008)J Biol Chem283, 19816-25.Goto, K. et al. (2011)Cell Death Dis2, e236.Alternate NamesBAG cochaperone 6; BAG family molecular chaperone regulator 6; BAG-6; BAG6; BAT3; BCL2 associated athanogene 6; BCL2-associated athanogene 6; D6S52E; G3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAG6; Large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe

BAG cochaperone 6; BAG family molecular chaperone regulator 6; BAG-6; BAG6; BAT3; BCL2 associated athanogene 6; BCL2-associated athanogene 6; D6S52E; G3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAG6; Large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe