BCL2L13 (E6G1Q) Rabbit Monoclonal Antibody#61974,Cell Signaling Technology (CST),61974

Bcl-2-like protein 13 (BCL2L13), also known as Bcl-rambo, is an atypical member of the Bcl-2 family of proteins that regulates apoptosis at the mitochondria (1). While it contains conserved Bcl-2 homology (BH) domains -1, -2, -3, and -4, it has a unique C-terminal region and does not interact with other Bcl-2 family members (1). BCL2L13 may regulate apoptosis in a cellular context manner (reviewed in 2). It was originally identified as a pro-apoptotic protein with activity dependent on its C-terminal region (1). Interaction with the adenine nucleotide translocator (ANT) suppresses the ADP/ATP-dependent translocation activity of ANT (3). Other studies have found that BCL2L13 can inhibit apoptosis in glioblastoma and tumor growth (4). These studies found that BCL2L13 binds to pro-apoptotic ceramide synthases 2 (CerS2) and 6 (CerS6) and blocks homo- and heteromeric CerS2/6 complex formation and activity. Studies have also found that BCL2L13 can regulate mitochondrial fragmentation and can bind to LC3 to facilitate the clearance of damaged mitochondria through mitophagy (5,6).Kataoka, T. et al. (2001)J Biol Chem276, 19548-54.Kataoka, T. (2022)Front Cell Dev Biol10, 1065702.Kim, J.Y. et al. (2012)FEBS Lett586, 3142-9.Jensen, S.A. et al. (2014)Proc Natl Acad Sci USA111, 5682-7.Murakawa, T. et al. (2015)Nat Commun6, 7527.Otsu, K. et al. (2015)Autophagy11, 1932-3.Alternate NamesB2L13; Bcl-2-like protein 13; Bcl-2L13; Bcl-rambo; BCL2 like 13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); BCL2L13; MIL1; Protein Mil1

B2L13; Bcl-2-like protein 13; Bcl-2L13; Bcl-rambo; BCL2 like 13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); BCL2L13; MIL1; Protein Mil1