BCOR (E6V3R) Rabbit Monoclonal Antibody#63972,Cell Signaling Technology (CST),63972

BCOR (E6V3R) Rabbit Monoclonal Antibody recognizes endogenous levels of total BCOR protein.

Host

Rabbit

Reactivity

Human, Monkey

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:50 Chromatin IP: 1:50

Platform ID

BAB403007137

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameBCOR (E6V3R) Rabbit Monoclonal Antibody#63972
Cat. No.63972
Accession NumberQ6W2J9
Gene ID (Entrez)54880
HostRabbit
SensitivityEndogenous
ReactivityHuman, Monkey
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:50 Chromatin IP: 1:50
Molecular Weight210, 110
ImmunogenIgG
FormulationFor optimal ChIP results, use 10 μl of antibody and 10 μg of chromatin (approximately 4 × 106cells) per IP. This antibody has been validated using SimpleChIP®Enzymatic Chromatin IP Kits.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

BCL6 corepressor protein (BCOR) is a ubiquitously expressed transcriptional repressor that is recruited to target genes by BCL6 and other transcription factors (1). BCOR interacts with and recruits histone deacetylase (HDAC) and DNA methyltransferase (DNMT) proteins to facilitate localized histone deacetylation and DNA methylation, resulting in repression of gene expression (1,2). Mutations and translocations involving BCOR have been observed in acute myeloid leukemia, bone sarcoma, and medulloblastoma, and mutations in BCOR are known to cause X-linked Oculofaciocardiodental and Lenz microphthalmia syndromes (3-6).Huynh, K.D. et al. (2000)Genes Dev14, 1810-23.Choi, W.I. et al. (2013)Nucleic Acids Res41, 6403-20.Grossmann, V. et al. (2011)Blood118, 6153-63.Pierron, G. et al. (2012)Nat Genet44, 461-6.Pugh, T.J. et al. (2012)Nature488, 106-10.Ng, D. et al. (2004)Nat Genet36, 411-6.Alternate Names5830466J11Rik; 8430401K06Rik; ANOP2; BCL-6 coreceptor; BCL-6 corepressor; BCL-6 interacting corepressor; BCL6 co-repressor; BCL6 corepressor; BCL6 interacting corepressor; BCOR; FLJ20285; FLJ38041; KIAA1575; MAA2; MCOPS2; MGC131961; MGC71031

Synonyms

5830466J11Rik; 8430401K06Rik; ANOP2; BCL-6 coreceptor; BCL-6 corepressor; BCL-6 interacting corepressor; BCL6 co-repressor; BCL6 corepressor; BCL6 interacting corepressor; BCOR; FLJ20285; FLJ38041; KIAA1575; MAA2; MCOPS2; MGC131961; MGC71031

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