BLVRA (F5Q9N) Rabbit Monoclonal Antibody#98784,Cell Signaling Technology (CST),98784

Biliverdin reductase A (BLVRA or BVRA) is responsible for the reduction of biliverdin, a product of heme oxygenase, to produce bilirubin, the end product of the heme catabolic pathway and major physiological antioxidant (1). In addition to its canonical role as an antioxidant, bilirubin acts as a powerful immunosuppressant and has hormonal activity that links it to a number of signaling pathways (reviewed in 2-4). Altered levels of bilirubin and BVRA have been reported in many pathological conditions, including cancer, cardiovascular, metabolic, and neurodegenerative diseases. Deletion of BLVRA leads to an increase in oxidative stress and autophagy impairment (5,6). BVRA has been shown to be a substrate of the insulin receptor and also phosphorylates insulin receptor substrate 1 (IRS-1) to regulate the insulin signaling pathway (7). Reduced BVRA expression is associated with changes in insulin signaling during obesity (8). BVRA phosphorylation of glycogen synthase kinase-3β (GSK-3β) inhibits its activity and phosphorylation of peroxisome proliferator-activated receptor α (PPARα), which protects from hepatic steatosis (9). Impairment of BVRA has been associated with Alzheimer’s disease (10-12). Levels of BVRA are frequently elevated in cancer, where it regulates several key mitogenic pathways (reviewed in 13).Komuro, A. et al. (1996)Biochim Biophys Acta1309, 89-99.Vitek, L. et al. (2023)Trends Mol Med29, 315-328.Creeden, J.F. et al. (2021)Am J Physiol Endocrinol Metab320, E191-E207.Kapitulnik, J. and Maines, M.D. (2009)Trends Pharmacol Sci30, 129-37.Gordon, D.M. et al. (2019)Arch Biochem Biophys672, 108072.Lanzillotta, C. et al. (2020)Antioxidants (Basel)9, 671. doi: 10.3390/antiox9080671.Lerner-Marmarosh, N. et al. (2005)Proc Natl Acad Sci USA102, 7109-14.Cimini, F.A. et al. (2019)Biochim Biophys Acta Mol Basis Dis1865, 1490-1501.Hinds, T.D. et al. (2016)J Biol Chem291, 25179-25191.Sharma, N. et al. (2019)Neurobiol Dis125, 176-189.Barone, E. et al. (2019)Mol Neurobiol56, 2922-2943.Triani, F. et al. (2018)Biochim Biophys Acta Mol Basis Dis1864, 3181-3194.Gibbs, P.E. et al. (2015)Front Pharmacol6, 119.Alternate NamesBIEA; Biliverdin reductase A; Biliverdin-IX alpha-reductase; BLVR; BLVRA; BVR; BVR A; BVRA; testis tissue sperm-binding protein Li 61n

BIEA; Biliverdin reductase A; Biliverdin-IX alpha-reductase; BLVR; BLVRA; BVR; BVR A; BVRA; testis tissue sperm-binding protein Li 61n