BRD7 (D9K2T) Rabbit Monoclonal Antibody#15125,Cell Signaling Technology (CST),15125

Bromodomain-containing protein 7 (BRD7, BP75, CELTIX-1) is a conserved bromodomain-containing protein that was first identified in a screen for proteins that interact with the PDZ domain of PSD95 (1). Subsequent studies identified BRD7 as a major component of SWI/SNF chromatin remodeling complexes, where it was shown to interact directly with acetylated histones to regulate gene transcription (2,3). BRD7 also interacts with p53, and was shown to participate directly in p53-dependent transcriptional regulation (4). Loss-of-function BRD7 mutations were identified in a subset of wild-type p53 breast cancer tumor samples, implicating BRD7 as a putative tumor-suppressor of potential clinical significance (5). BRD7 also associates with the BRCA1 protein, an interaction that facilitates recruitment of BRCA1 to the ERα gene promoter (6).Cuppen, E. et al. (1999)FEBS Lett459, 291-8.Peng, C. et al. (2006)J Cell Biochem97, 882-92.Kaeser, M.D. et al. (2008)J Biol Chem283, 32254-63.Burrows, A.E. et al. (2010)Proc Natl Acad Sci U S A107, 14280-5.Drost, J. et al. (2010)Nat Cell Biol12, 380-9.Harte, M.T. et al. (2010)Cancer Res70, 2538-47.Alternate Names75 kDa bromodomain protein; BP75; BRD7; bromodomain containing 7; bromodomain protein; bromodomain-containing 7; Bromodomain-containing protein 7; CELTIX1; NAG4; Protein CELTIX-1

75 kDa bromodomain protein; BP75; BRD7; bromodomain containing 7; bromodomain protein; bromodomain-containing 7; Bromodomain-containing protein 7; CELTIX1; NAG4; Protein CELTIX-1