Bacillus anthracis Lethal Factor antibody [5F502.2],Genetex,GTX13814
Host
Mouse
Reactivity
Bacillus anthracis
Application
WB
Conjugate
Unconjugated
Platform ID
BAB225648632
Genetex
Contact
Tel: 1-949-553-1900
Fax: 1-949-309-2888
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Product Specifications
Scientific Background
Specifications
NameBacillus anthracis Lethal Factor antibody [5F502.2]
Cat. No.GTX13814
HostMouse
IsotypeIgG1
ReactivityBacillus anthracis
ConjugationUnconjugated
ApplicationWB
ClonalityMonoclonal
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration.)
ImmunogenThe antibody was developed by immunizing rabbits with a synthetic peptide corresponding to amino acids 779-792 of the Anthrax LF protein (approx. 90 kD).
PurityProtein G purified
Appearance/FormLiquid
FormulationPBS, 0.05% BSA,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only
Scientific Background
Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxicity to occur. It begins with the binding of PA to its cell-surface receptor, ATR (Anthrax Toxin Receptor), at which point PA is cleaved and the resulting 63 kD carboxyl-terminal fragment binds to LF and EF. LF is a protease that is known to cleave members of the mitogen-activated protein kinase kinase (MAPKK) family.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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