Bcl-xL (54H6) Rabbit Monoclonal Antibody (BSA and Azide Free)#61060,Cell Signaling Technology (CST),61060

Bcl-xL (54H6) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total Bcl-xL protein. This antibody does not cross-react with other Bcl-xL proteins.

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Platform ID

BAB340425926

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameBcl-xL (54H6) Rabbit Monoclonal Antibody (BSA and Azide Free)#61060
Cat. No.61060
Accession NumberQ07817
Gene ID (Entrez)7817
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat, Monkey
Molecular Weight30
ImmunogenIgG
FormulationThis product is the carrier-free version of product #2764. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, pleasecontact us. Optimal dilutions/concentrations should be determined by the end user.BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
StorageStore at -20°C.This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles.A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
Regulatory StatusResearch Use Only

Scientific Background

Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect (1,2) and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions (3). Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents, such as paclitaxel, vinblastine, and nocodazole (4,5).Adams, J.M. and Cory, S. (1998)Science281, 1322-6.Minn, A.J. et al. (1999)EMBO J18, 632-43.Vander Heiden, M.G. et al. (2001)J Biol Chem276, 19414-9.Fan, M. et al. (2000)J Biol Chem275, 29980-5.Poruchynsky, M.S. et al. (1998)Cancer Res58, 3331-8.Alternate NamesApoptosis regulator Bcl-X; B2CL1; Bcl-2-like protein 1; Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2 like 1; Bcl2-L-1; BCL2-like 1; BCL2L; BCL2L1; BCLX; BCLXL; BCLXS; DKFZp781P2092; PPP1R52; protein phosphatase 1, regulatory subunit 52

Synonyms

Apoptosis regulator Bcl-X; B2CL1; Bcl-2-like protein 1; Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2 like 1; Bcl2-L-1; BCL2-like 1; BCL2L; BCL2L1; BCLX; BCLXL; BCLXS; DKFZp781P2092; PPP1R52; protein phosphatase 1, regulatory subunit 52

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