Biotin Anti-CD59 antibody [MEM-43],Abcam,AB28114

The antibody is conjugated with Biotin-LC-NHS and it is free of unconjugated biotin.

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Conjugate

Biotin

Platform ID

BAB039391641

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameBiotin Anti-CD59 antibody [MEM-43]
Cat. No.AB28114
HostMouse
IsotypeIgG2a
ReactivityHuman
ConjugationBiotin
ApplicationFlow Cyt
ClonalityMonoclonal
Clone NumberMEM-43
Concentration1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing CD59 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed : 11882685, PubMed : 1698710, PubMed : 2475111, PubMed : 2475570, PubMed : 2606909, PubMed : 9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed : 11882685, PubMed : 1698710, PubMed : 36797260).. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. See full target information CD59

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