Biotin Anti-Thyroglobulin antibody,Abcam,AB49556

Host

Rabbit

Reactivity

Human

Application

ELISA, IP, WB, RIA

Conjugate

Biotin

Platform ID

BAB104671556

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameBiotin Anti-Thyroglobulin antibody
Cat. No.AB49556
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationBiotin
ApplicationELISA, IP, WB, RIA
ClonalityPolyclonal
Concentration0.3 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human Thyroglobulin.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.25% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed : 17532758, PubMed : 32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed : 32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed : 32025030). One dimer produces 7 thyroid hormone molecules (PubMed : 32025030). See full target information Thyroglobulin

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