Biotin anti-CX3CR1 Antibody anti-CX3CR1 - 8E10.D9,BioLegend,824004

This antibody is effective in Immunoblotting (WB) and immunohistochemistry (IHC) for the relevant formats of this clone.

Host

Mouse

Reactivity

Human

Application

IHC-P - Quality tested

Platform ID

BAB385560573

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBiotin anti-CX3CR1 Antibody anti-CX3CR1 - 8E10.D9
Cat. No.824004
HostMouse
RRIDAB_2650684 (BioLegend Cat. No. 824004)
IsotypeMouse IgG1, λ
ReactivityHuman
ApplicationIHC-P - Quality tested
ClonalityMonoclonal
Clone Number8E10.D9
Concentration0.5 mg/ml
TargetCX3CR1
ImmunogenThis monoclonal antibody was raised against a peptide sequence conjugated to KLH corresponding to amino acids 207-222 of the human CX3CR1 protein.
PurityThe antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CX3C chemokine receptor 1 (CX3CR1) also known as fractalkine receptor or G-protein coupled receptor 13, is a receptor that binds the chemokine CX3CL1. CX3CR1 expression is associated with T cells, NK cells, and brain microglia. CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. CX3CL1 is expressed by activated-endothelial cells, neurons, and astrocytes. The interaction of CX3CR1 and its ligand mediates cell adhesion and migration. CX3CL1 has been reported to play an important role in neuroinflammation and neurodegeneration.

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