Biotin anti-TFAM Antibody, TFAM, 18G102B2E11,BioLegend,850505
This antibody recognizes endogenous TFAM in human brain tissues in WB and IHC applications but does not recognize mouse TFAM.
Host
Mouse
Reactivity
Human
Application
WB -Quality tested
Platform ID
BAB480937299
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameBiotin anti-TFAM Antibody, TFAM, 18G102B2E11
Cat. No.850505
HostMouse
RRIDAB_2801185 (BioLegend Cat. No. 850505)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationWB -Quality tested
ClonalityMonoclonal
Clone Number18G102B2E11
Concentration0.5 mg/ml
TargetTFAM
ImmunogenFull-length human TFAM protein
PurityThe antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
TFAM (Transcription Factor A, Mitochondrial) binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation, and DNA replication and repair. The protein is required for accurate and efficient promoter recognition by mitochondrial RNA polymerase. Sequence polymorphisms in the TFAM gene are associated with Alzheimer's and Parkinson's diseases. Other diseases associated with TFAM include Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form and Deoxyguanosine Kinase Deficiency.
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