Biotin anti-human CD273 B7-DC, PD-L2 Antibody anti-CD273 - MIH18,BioLegend,345510
Additional reported applications (for the relevant formats) include: blocking4,5, and immunohistochemistry in frozen sections2and paraffin-embedded formalin-fixed sections6. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 345504).
Host
Mouse
Reactivity
Human
Application
FC -Quality tested
Platform ID
BAB879302314
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions. Clone MIH18 is reported to block PDL2.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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