Biotin anti-mouse CD106 Antibody anti-CD106 - 429 (MVCAM.A),BioLegend,105703

Additional reported applications (for the relevant formats) include: immunohistochemical staining2,3,5-7of acetone-fixed frozen sections, blocking4,5,8of ligand bindingin vitroandin vivo, immunoprecipitation1, and spacial biology (IBEX)11,12. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 105727 & 105728).

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB309485842

BioLegend

Headquarters

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BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBiotin anti-mouse CD106 Antibody anti-CD106 - 429 (MVCAM.A)
Cat. No.105703
HostRat
RRIDAB_313204 (BioLegend Cat. No. 105703)AB_313205 (BioLegend Cat. No. 105704)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number429 (MVCAM.A)
Concentration0.5 mg/ml
TargetCD106
ImmunogenMouse preadipose cell line PA6
PurityThe antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4/β1integrin) and LPAM-1 (α4/β7integrin). The 429 antibody has been reported to partially block VCAM-1-mediated binding.

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