Biotin anti-mouse/rat beta-Amyloid, 1-16 Antibody anti-beta-Amyloid, 1-16 - M3.2,BioLegend,805704

Clone M3.2 recognizes a rodent sequence of Aß, ß-CTF, sAPP-a, and full length APP. Clone 3.2 has negligible cross reactivity with human isoforms of APP and beta amyloid.

Host

Mouse

Reactivity

Mouse, Rat

Application

WB - Quality testedICC - Reported in the literature, not verified in houseELISA

Platform ID

BAB061048827

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBiotin anti-mouse/rat beta-Amyloid, 1-16 Antibody anti-beta-Amyloid, 1-16 - M3.2
Cat. No.805704
HostMouse
RRIDAB_2564984 (BioLegend Cat. No. 805703)AB_2564983 (BioLegend Cat. No. 805704)
IsotypeMouse IgG1, κ
ReactivityMouse, Rat
ApplicationWB - Quality testedICC - Reported in the literature, not verified in houseELISA
ClonalityMonoclonal
Clone NumberM3.2
Concentration1 mg/mL
Targetbeta-Amyloid 1-16
ImmunogenThe epitope has been determined to be within residues 10-15 of murine Aβ.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution; no preservatives or carrier proteins.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Regulatory StatusResearch Use Only

Scientific Background

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

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