Biotinylated Anti-SN38 Antibody, Mouse IgG1, AvitagTM,Acro Biosystems,SN8-BVM808
Biotinylated Anti-SN38 Antibody, Mouse IgG1, Avitag is a Mouse monoclonal antibody recombinantly expressed from HEK293 cells.
Application
ELISA
Conjugate
Biotin
Platform ID
BAB779881093
Acro Biosystems
Contact
Tel: +1 800-810-0816
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Product Specifications
Specifications
NameBiotinylated Anti-SN38 Antibody, Mouse IgG1, AvitagTM
Cat. No.SN8-BVM808
IsotypeMouse IgG1 & C-Avi | Mouse Kappa
ConjugationBiotin
ApplicationELISA
Working Dilutions0.1-125 ng/mL
ImmunogenSN38-OVA
FormulationLyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.
Please contact us for customized product forms or formulations.
ReconstitutionPlease refer to the Certificate of Analysis (CoA) for specific instructions.
For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.
StorageDxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS-8201A). Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 (IC50, > 10000 - mL). HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody. It can be used in PK, PD analysis and ELISA.
Category Paths
- Products>Primary Antibodies>Conjugated Antibodies
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