Brilliant Violet 421™ anti-Human/Mouse CD266 (Fn14/TWEAKR), CD266, ITEM-4,BioLegend,314109

Additional reported applications (for the relevant formats) include: Western blotting3,4, immunofluorescence3,4, and immunohistochemistry of frozen sections5and formalin-fixed paraffin-embedded sections3. ITEM-4 antibody has no effect on TWEAK-induced MAPK activation in RAW cells1.

Host

Mouse

Reactivity

Human, Mouse

Application

FC - Quality tested

Platform ID

BAB927390485

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Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 421™ anti-Human/Mouse CD266 (Fn14/TWEAKR), CD266, ITEM-4
Cat. No.314109
HostMouse
RRIDAB_3683328 (BioLegend Cat. No. 314109)AB_3683328 (BioLegend Cat. No. 314110)
IsotypeMouse IgG2b, κ
ReactivityHuman, Mouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberITEM-4
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD266
ImmunogenHuman Fn14 transfected P815
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.

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