Brilliant Violet 421 anti-human CD11c Antibody anti-CD11c - S-HCL-3,BioLegend,371511

Additional reported applications (for the relevant formats) include: immunohistochemistry on frozen tissue sections1,2,3,4and immunoprecipitation1.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB151016886

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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 421 anti-human CD11c Antibody anti-CD11c - S-HCL-3
Cat. No.371511
HostMouse
RRIDAB_2650794 (BioLegend Cat. No. 371511)AB_2650795 (BioLegend Cat. No. 371512)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS-HCL-3
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD11c
ImmunogenSpleen cells from patient diagnosed with hairy cell leukemia.
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αxand CR4. CD11c non-covalently associates with integrin β2(CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.

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