Brilliant Violet 421 anti-mouse CD134 OX-40 Antibody anti-CD134 - OX-86,BioLegend,119411

Clone OX-86 has been reported to act as an agonist and stimulate OX-40.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB263585356

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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 421 anti-mouse CD134 OX-40 Antibody anti-CD134 - OX-86
Cat. No.119411
HostRat
RRIDAB_10962569 (BioLegend Cat. No. 119411)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberOX-86
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD134
ImmunogenRecombinant mouse OX-40-CD4 chimeric protein
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD134 is a type I integral membrane protein also known as OX-40, ACT35, and tumor necrosis factor receptor superfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+and CD8+T cells and B cells. The OX-40 receptor binds to the OX-40 ligand (CD252) to provide a costimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.

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