Brilliant Violet 421 anti-mouse CD183 CXCR3 Antibody anti-CD183 - CXCR3-173,BioLegend,126521

Clone CXCR3-173 does not work for Western blotting.7Forin vivostudies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 126526) with endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered.

Host

Armenian Hamster

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB716957748

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 421 anti-mouse CD183 CXCR3 Antibody anti-CD183 - CXCR3-173
Cat. No.126521
HostArmenian Hamster
RRIDAB_10900974 (BioLegend Cat. No. 126521)AB_2563100 (BioLegend Cat. No. 126529)AB_2562205 (BioLegend Cat. No. 126522)
IsotypeArmenian Hamster IgG
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberCXCR3-173
Concentrationµg sizes: 0.2 mg/mLµL sizes: lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD183
ImmunogenMouse N-terminus of CXCR3
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.

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