Brilliant Violet 421 anti-mouse/human KLRG1 MAFA Antibody anti-KLRG1 - 2F1/KLRG1,BioLegend,138413

For successful staining of human cells, brighter fluorophore-antibody conjugates, such as PE, BV421™, or APC, are recommended.Additional reported applications (for relevant formats) include: Western Blotting1.

Host

Syrian Hamster

Reactivity

Mouse, Human

Application

FC - Quality tested

Platform ID

BAB552913998

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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 421 anti-mouse/human KLRG1 MAFA Antibody anti-KLRG1 - 2F1/KLRG1
Cat. No.138413
HostSyrian Hamster
RRIDAB_10918627 (BioLegend Cat. No. 138413)AB_2565613 (BioLegend Cat. No. 138414)
IsotypeSyrian Hamster IgG
ReactivityMouse, Human
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number2F1/KLRG1
Concentrationµg sizes: 0.2 mg/mLµL sizes: lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetKLRG1
ImmunogenIL-2 activated NK cells from C57BL/6 mice
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag).  KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3.  It is composed of a homodimer of glycosylated 30-38 kD subunits.  Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells.  KLRG1 is also expressed on subsets of CD8+and CD4+cells, including CD4+and CD8+effector/memory cells, potent regulatory CD4+T cells.  KLRG1 may be involved in regulating NK cell homeostasis.  KLRG1 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

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