Brilliant Violet 510 anti-human CD123 Antibody anti-CD123 - 6H6,BioLegend,306021
Clone 6H6 does not inhibit IL-3 binding to low- or high-affinity IL-3Rs. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, and immunohistochemical staining of acetone-fixed frozen sections2and also paraformaldehyde fixed paraffin embedded tissue7.
Host
Mouse
Reactivity
Human
Application
FC - Quality tested
Platform ID
BAB070955334
BioLegend
Contact
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Product Specifications
Scientific Background
Specifications
NameBrilliant Violet 510 anti-human CD123 Antibody anti-CD123 - 6H6
Cat. No.306021
HostMouse
RRIDAB_2562067 (BioLegend Cat. No. 306021)AB_2562068 (BioLegend Cat. No. 306022)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number6H6
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD123
ImmunogenHuman IL-3Rα transfected COS cells.
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 510™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CD131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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