Brilliant Violet 510 anti-human CD161 Antibody anti-CD161 - HP-3G10,BioLegend,339921

Additional reported applications (for the relevant formats) include: inhibition of cytokine production and Western blotting under nonreducing conditions.

Host

Mouse

Reactivity

Human, Rhesus

Application

FC - Quality tested

Platform ID

BAB112135558

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 510 anti-human CD161 Antibody anti-CD161 - HP-3G10
Cat. No.339921
HostMouse
RRIDAB_2562933 (BioLegend Cat. No. 339921)AB_2562934 (BioLegend Cat. No. 339922)
IsotypeMouse IgG1, κ
ReactivityHuman, Rhesus
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberHP-3G10
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD161
ImmunogenHuman NK cells
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 510™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.

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