Brilliant Violet 605™ anti-mouse CD45 Antibody, CD45, I3/2.3,BioLegend,147723

Additional reported applications (for the relevant formats) include: immunohistochemical staining of paraffin embedded sections1and frozen tissue sections2.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB487722776

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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 605™ anti-mouse CD45 Antibody, CD45, I3/2.3
Cat. No.147723
HostRat
RRIDAB_3662408 (BioLegend Cat. No. 147723)
IsotypeRat IgG2b, λ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberI3/2.3
Concentration0.2 mg/mL
TargetCD45
ImmunogenMouse lymphoma cell line
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from alternative splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

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