Brilliant Violet 711 anti-human TCR Valpha24-Jalpha18 iNKT cell Antibody anti-TCR V alpha 24-J alpha 18 - 6B11,BioLegend,342921
The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.
Host
Mouse
Reactivity
Human
Application
FC - Quality tested
Platform ID
BAB694468548
BioLegend
Contact
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Product Specifications
Scientific Background
Specifications
NameBrilliant Violet 711 anti-human TCR Valpha24-Jalpha18 iNKT cell Antibody anti-TCR V alpha 24-J alpha 18 - 6B11
Cat. No.342921
HostMouse
RRIDAB_2572067 (BioLegend Cat. No. 342921)AB_2572068 (BioLegend Cat. No. 342922)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number6B11
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetTCR Valpha24-Jalpha18
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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