Brilliant Violet 711™ anti-human TIGIT (VSTM3) Antibody, TIGIT (VSTM3), A15153G,BioLegend,372742

This clone can suppress anti-CD3 induced T cell proliferationin vitrobased on in-house testing.This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).Additional reported applications (for the relevant formats) include: Blocking1.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB735037801

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 711™ anti-human TIGIT (VSTM3) Antibody, TIGIT (VSTM3), A15153G
Cat. No.372742
HostMouse
RRIDAB_2904404 (BioLegend Cat. No. 372741)AB_2904404 (BioLegend Cat. No. 372742)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA15153G
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetTIGIT
ImmunogenRecombinant Human TIGIT.
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12.

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