Brilliant Violet 711™ anti-mouse CD357 (GITR) Antibody, CD357, DTA-1,BioLegend,126333

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB157125217

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 711™ anti-mouse CD357 (GITR) Antibody, CD357, DTA-1
Cat. No.126333
HostRat
RRIDAB_3097506 (BioLegend Cat. No. 126333)
IsotypeRat IgG2b, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberDTA-1
Concentration0.2 mg/mL
TargetCD357
ImmunogenMouse CD25+CD4+T cells
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF receptor superfamily, also known as TNFRSF18 and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-κB activation, and abrogate the inhibitory function of CD25+CD4+Tregs.In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.