Brilliant Violet 785 anti-human CD226 DNAM-1 Antibody anti-CD226 - 11A8,BioLegend,338321

Additional reported applications include: block NK cell-mediated lysis.

Host

Mouse

Reactivity

Human

Application

FC -Quality tested

Platform ID

BAB601202073

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameBrilliant Violet 785 anti-human CD226 DNAM-1 Antibody anti-CD226 - 11A8
Cat. No.338321
HostMouse
RRIDAB_2721559 (BioLegend Cat. No. 338321)AB_2721560 (BioLegend Cat. No. 338322)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone Number11A8
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD226
PurityThe antibody was purified by affinity chromatography and conjugated with Brilliant Violet 785™ under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-set. The ligands for CD226 are the poliovirus receptor (CD155) and its family member nectin-2 (CD112), which are broadly expressed on epithelial, endothelial and neuronal cells. CD226 is physically associated with LFA-1 in NK cells and activated T cells, and involved in LFA-1-mediated signaling.

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