CD11c (D1V9Y) Rabbit Monoclonal Antibody#97585,Cell Signaling Technology (CST),97585

CD11c (D1V9Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD11c protein. Non-specific staining of the epithelium in fixed frozen mouse intestine was observed by immunofluorescence. Non-specific staining in fixed frozen mouse brain was observed by immunofluorescence.

Host

Rabbit

Reactivity

Mouse

Application

Western Blotting: 1:1000 IHC Leica Bond: 1:150 - 1:600 Immunohistochemistry (Paraffin): 1:150 - 1:600 Immunofluorescence (Frozen): 1:100 - 1:400 Immunofluorescence (Immunocytochemistry): 1:100 - 1:400

Platform ID

BAB030818287

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCD11c (D1V9Y) Rabbit Monoclonal Antibody#97585
Cat. No.97585
Accession NumberQ9QXH4
Gene ID (Entrez)16411
HostRabbit
SensitivityEndogenous
ReactivityMouse
ApplicationWestern Blotting: 1:1000 IHC Leica Bond: 1:150 - 1:600 Immunohistochemistry (Paraffin): 1:150 - 1:600 Immunofluorescence (Frozen): 1:100 - 1:400 Immunofluorescence (Immunocytochemistry): 1:100 - 1:400
Molecular Weight145
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #39143.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #39143.
Regulatory StatusResearch Use Only

Scientific Background

CD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins (1). CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production (2, 3). CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia (4-7).Uotila, L.M. et al. (2013)J Biol Chem288, 33494-9.Kohrgruber, N. et al. (1999)J Immunol163, 3250-9.Siegal, F.P. et al. (1999)Science284, 1835-7.Racine, R. et al. (2008)J Immunol181, 1375-85.Werfel, T. et al. (1991)J Immunol147, 2423-7.Cabañas, C. et al. (1988)Hybridoma7, 167-76.Kristensen, J.S. et al. (1987)Blood70, 1063-8.Alternate NamesAI449405; CD11 antigen-like family member C; Cd11c; CD11C (p150) alpha polypeptide; complement receptor 4; Cr4; integrin alpha X; Integrin alpha-X; integrin aX; ITAX; Itgax; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; mFLJ00114; MFLJ00114 protein; N418

Synonyms

AI449405; CD11 antigen-like family member C; Cd11c; CD11C (p150) alpha polypeptide; complement receptor 4; Cr4; integrin alpha X; Integrin alpha-X; integrin aX; ITAX; Itgax; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; mFLJ00114; MFLJ00114 protein; N418

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.