CD146 antibody [C1C3],Genetex,GTX108777

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB ICC/IF IHC-P

Conjugate

Unconjugated

Platform ID

BAB310230542

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCD146 antibody [C1C3]
Cat. No.GTX108777
Gene ID (Entrez)4162
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P
ClonalityPolyclonal
Concentration0.21 mg/ml (Please refer to the vial label for the specific concentration.)
TargetMCAM
ImmunogenRecombinant protein encompassing a sequence within the C-terminus region of human CD146. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 1% BSA, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Synonyms

melanoma cell adhesion molecule , CD146 , HEMCAM , METCAM , MUC18 , MelCAM

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