CD177 Antibody#25068,Cell Signaling Technology (CST),25068

Cluster of differentiation 177 antigen (CD177, also known as human neutrophil alloantigen 2a and NB1), is a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated transmembrane protein expressed primarily on the surface of neutrophils (1,2). Expression of CD177 can be induced by granulocyte-colony-stimulating factor and during pregnancy or bacterial infection (3-5). CD177 mediates adhesion and transendothelial migration of neutrophils via interaction with CD31/PECAM-1 and integrin β2 on endothelial cells (6,7). CD177 also promotes the cell surface expression of proteinase 3 (PR3), which may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (8-10). In association with CD11b/ITGAM, integrin β2, and PR3, CD177 promotes activation of TNF-α primed neutrophils including degranulation and superoxide production (11).CD177 is a polymorphic gene that has been linked to several important clinical diseases, including polycythemia vera, Wegener’s granulomatosis, and immune mediated neonatal neutropenia (12-14).Matsuo, K. et al. (2000)Transfusion40, 654-62.Xie, Q. et al. (2015)Protein Cell6, 117-26.Stroncek, D.F. et al. (1998)Transfusion38, 663-8.Caruccio, L. et al. (2003)Transfusion43, 357-63.Göhring, K. et al. (2004)Br J Haematol126, 252-4.Sachs, U.J. et al. (2007)J Biol Chem282, 23603-12.Bai, M. et al. (2017)Blood130, 2092-100.von Vietinghoff, S. et al. (2007)Blood109, 4487-93.von Vietinghoff, S. et al. (2008)Clin Exp Immunol152, 508-16.Kuckleburg, C.J. and Newman, P.J. (2013)Arterioscler Thromb Vasc Biol33, 275-84.Jerke, U. et al. (2011)J Biol Chem286, 7070-81.Lalezari, P. et al. (1971)J Clin Invest50, 1108-15.Bettinotti, M.P. et al. (2002)Clin Immunol102, 138-44.Caruccio, L. et al. (2006)Transfusion46, 441-7.Alternate Names1190003K14Rik; Cd177; CD177 antigen; Pdp3

1190003K14Rik; Cd177; CD177 antigen; Pdp3