CD20 (2H7) Mouse Monoclonal Antibody (APC Conjugate)#69077,Cell Signaling Technology (CST),69077

B-lymphocyte antigen CD20 (also known as MS4A1; Membrane-spanning 4-domains subfamily A member 1) is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation (1,2). It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse (1-3). Evidence suggests that CD20 is necessary for store operated calcium (SOC) entry, which leads to elevated cytoplasmic calcium levels required for B cell activation (4,5). Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases (6).The 2H7 antibody is widely used to identify both normal and malignant B cells (7).Stashenko, P. et al. (1980)J Immunol125, 1678-85.Tedder, T.F. et al. (1985)J Immunol135, 973-9.Tedder, T.F. et al. (1988)J Immunol141, 4388-94.Bubien, J.K. et al. (1993)J Cell Biol121, 1121-32.Li, H. et al. (2003)J Biol Chem278, 42427-34.Uchida, J. et al. (2004)J Exp Med199, 1659-69.Liu, A.Y. et al. (1987)J Immunol139, 3521-6.Alternate NamesB-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; B1; Bp35; CD20; CD20 antigen; CD20 receptor; CVID5; LEU-16; Leukocyte surface antigen Leu-16; membrane spanning 4-domains A1; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; MGC3969; MS4A1; MS4A2; S7

B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; B1; Bp35; CD20; CD20 antigen; CD20 receptor; CVID5; LEU-16; Leukocyte surface antigen Leu-16; membrane spanning 4-domains A1; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; MGC3969; MS4A1; MS4A2; S7